This idea was first proposed as a public health measure two decades ago, but when the Food and Drug Administration (FDA) argued the case before the Supreme Court in 2000, they were not granted the authority. Times have changed, though, and in 2009 the Tobacco Control Act granted the FDA vastly greater regulatory power over tobacco products, including the authority to reduce nicotine if it is deemed likely to improve public health. But while small studies have shown the possible benefits of such a move, no large trial has compared the effects of regular- and reduced-nicotine cigarettes on smoking behavior, dependence, and subjective measures of smoking … until now.
Number of Cigarettes Smoked per Day According to Nicotine Content.
The mean number of cigarettes smoked per day was based on the number reported by participants with the use of an interactive voice-response system. Panel A shows the mean total number of cigarettes smoked per day, including both study and nonstudy cigarettes. Panel B shows the mean number of study cigarettes smoked per day. All analyses were adjusted for the baseline number of cigarettes smoked per day. An asterisk indicates P<0.001 for the comparison at week 6 with the primary control cigarettes (those with 15.8 mg of nicotine per gram of tobacco.
Number of Cigarettes Smoked per Day According to Nicotine Content.
The mean number of cigarettes smoked per day was based on the number reported by participants with the use of an interactive voice-response system. Panel A shows the mean total number of cigarettes smoked per day, including both study and nonstudy cigarettes. Panel B shows the mean number of study cigarettes smoked per day. All analyses were adjusted for the baseline number of cigarettes smoked per day. An asterisk indicates P<0.001 for the comparison at week 6 with the primary control cigarettes (those with 15.8 mg of nicotine per gram of tobacco.
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